Steroids: A manipulative hormone for Humans | Mucormycosis | Black Fungus

Introduction 

Steroids are man-made a version of chemicals, which also known as a hormone, that has made naturally in the human body. Steroids have designated to act like these hormones to reduces inflammation.

They are also known as corticosteroids and differently used by bodybuilders and athletes.

Basically, steroids don’t help in reducing inflammation and will ease symptoms such as swelling pain, and stiffness.

Steroid can used to reduce this immune reaction.

Usually, inflammation is the body’s natural reaction to infections or bacteria which causes swelling, redness, and heat in the affected area.

Applications of Steroid:

Applications of Steroid

Steroids are usually given for a short time to quickly treat flare-ups of your condition. Depending on which condition you have and what doses you are prescribed you may notice an improvement in your symptoms within a few days.

Steroids helps in treating a wide range of conditions like 

  • Asthma and chronic obstructive pulmonary disease (CPOD).
  • High fever.
  • Hives and eczema.
  • Arthritis and frozen shoulder.
  • Pain caused by an irritated or trapped nerve such as Sciatica.
  • Inflammatory Bowel Syndrome(IBS)
  • Lupus
  • Multiple Sclerosis.

Types of Steroids:

Steroid came in many different forms. The main type are 

  • Tablets/Syrups and liquids.
  • Inhalers and nasal sprays.
  • Injections.
  • Creams and lotions.

Most steroids are only available on prescription, but a few can be bought from pharmacies and shops.

Side effects and risks of Steroids :

As with other medicines, Some people will have side effects. These are more likely if you’re on a high dose or if you’re taking steroids for a long time 

The person treating you will make sure you’re on the lowest possible dose to keep your condition under control.

However, you might also give a drug called proton pump inhibitor or another medicine to protect your stomach.

Some side effects of steroid:

 Tablet, liquids, and soluble tablets.

Steroids - side effects
  • Weight gain and increased appetite.
  • Stomach pain, indigestion, or heartburn.
  • Sleep problems.
  • Changes in mood.
  • Bruising easily.
  • Thinning of the skin.
  • Stretch marks.

Cream and gels

  • Stinging or burning where the creams have been applied.
  • Change in skin color.
  • Increased hair growth where the cream has applied.

Eyedrops and liquid

  • Stinging or burning in eyes after putting drops in.
  • A funny taste in the mouth after putting drops in.

Treatments with steroids may cause changes in the mood you may feel very high or very low. This may feel very high or very low. This may be more common in people with a previous history of mood disturbance.

Steroids taken for a long time can also cause your muscle to become weaker, and they might occasionally affect periods in women.

Hindustan Times note on Steroids:

Misuse of steroids major cause behind Mucormycosis infection: AIIMS chief.

Doctors say cases of the mucormycosis infection, also known as the ‘black fungus’, are on the rise. It is sometimes causing more deaths than Covid-19, they say, adding that misuse of steroids should be controlled since a weakened immune system is a major cause behind the fungal infection.

AIIMS director Dr. Randeep Guleria on Saturday warned that cases of mucormycosis infection, commonly known as the ‘Black Fungus’, are on the rise in the wake of the coronavirus disease (Covid-19) among, particularly susceptible patients. Misuse of steroids is a major cause behind this infection, he said, adding that patients who are diabetic or Covid-19 positive and are taking steroids have an increased chance of contracting the fungal infection.

To prevent the mucormycosis infection, misuse of steroids must be stopped, said the director of the All India Institute of Medical Sciences (AIIMS) in New Delhi. Dr. Guleria added that such secondary infections, which include fungal and bacterial, are causing more mortality in recent days, even as Covid-19 cases keep on increasing. 

Origin of Mucormycosis.

Mucormycosis symptoms- Black fungus - corona Virus

Mucormycosis spores were found in soil, air, and even in food, said the AIIMS chief.

In a new advisory over black fungus infection, the central government asked people to be extra careful regarding infection protocols since the mucormycosis fungus enters the body through a cut, scrape, burn, or other types of skin trauma when the skin comes in contact with fungal spores in the environment.

As such, a few of the conditions in which a Covid-19 patient might find themselves to be at an increased risk of the mucormycosis infection are:

1. If they are visiting dusty construction sites without masks.

2. If they are not wearing shoes, long trousers, long sleeve shirts, and gloves while handling soil (gardening), moss, or manure.

3. If they have experienced prolonged hospital or ICU stay.

4. If they are co-morbid, have undergone organ transplant, or are suffering from cancer.

5. If they are not maintaining personal hygiene properly in general.

Covid-19 patients and steroids:

Covid-19 patients and steroids

Dr. Randeep Guleria, AIIMS chief, said that the mucormycosis fungal spores are of low virulence and usually do not cause infection. There were very few cases before Covid-19, but moreover, a large number of cases are only being reported in recent times due to the coronavirus disease infection, as a result, It affects immunity. Since steroids like dexamethasone also repress the immune system, it is also necessary to be extra careful regarding their use, now more so than ever.

Most importantly, Overuse, misuse, and rampant use of steroids in Covid-19 patients can cause black fungus, also known as mucormycosis,” said Dr. Suresh Kumar, medical director of LNJP hospital in New Delhi.

He said that steroid use must reduce. If given to patients with oxygen levels over 90, black fungus is a possible side-effect. Early diagnosis is critical. A CT scan of the face would detect this infection, after which antifungal drug amphotericin will be used for treatment

Summary:

In conclusion, their discovery, steroids have infiltrated nearly every branch of medicine and can also be administered in nearly every route available. The effects of steroid use can vary widely, and the full spectrum of side effects can be present even in patients taking low doses.

Practitioners must be aware that the drug can possibly exacerbate a preexisting condition or present a new medical condition. Knowledge of the clinical implications of prescribing these agents is critical.

FAQ :-

where was mucormycosis found

Mucormycosis spores were found in soil, air, and even in food

what is mucormycosis symptoms

The mucormycosis symptoms depend on where the fungus is growing. The symptoms are One-sided facial swelling, fever, cough, chest pain, Abdominal pain, Gastrointestinal bleeding, Nausea, and vomiting.

why mucormycosis in covid patients

Most importantly, Overuse, misuse, and rampant use of steroids in Covid-19 patients can cause black fungus, also known as mucormycosis,” said Dr. Suresh Kumar, medical director of LNJP hospital in New Delhi.

How mucormycosis is diagnosed

diagnose mucormycosis with fluid or tissue samples send them to a lab and Other tests may include CT scan or MRI

References:

https://www.versusarthritis.org

https://www.nhs.uk/conditions/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3636985/

2 Comments

  1. well described everything in-depth ! Was not knowing this much before about steriods . thanks 🙂

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